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- **Choosing Your North Star Metric**

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- **A Practical Guide to NFT Memberships for Creators**

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**Featured posts**

## What the Merge Means for Ethereum

Danny Ryan and Jeff Benson

The Ethereum Foundation's Danny Ryan discusses how the Merge will increase security and explains how proof of stake impacts developers.

## Jason Fried on Why He Doesn’t Do Planning or Politics at Work

Jason Fried and Lauren Murrow

The Basecamp and HEY founder discusses the power of short-term thinking, his framework for startup longevity, and the key thing he looks for when hiring remote.

## How to Build a GPT-3 for Science

Josh Nicholson

A GPT-3-like AI model for science would accelerate innovation and improve reproducibility. Creating it will require us to unlock scientific publications.

## Why Developers Are Building So Many Side Projects

Ben Stokes

From unleashing creativity to mitigating risk, Ben Stokes of Tiny Projects shares some of the main reasons why developers are building so many side projects.

## What’s After Proof of Stake for Ethereum?

Danny Ryan and Jeff Benson

Danny Ryan details the path forward for scalability and explains the possibility of stateless Ethereum, while sharing how the Merge will affect future upgrades.

Latest

### Why Applying Machine Learning to Biology is Hard – But Worth It

Jimmy Lin and Nicole Neuman

### Did We Overeat on Software?

Andrej Safundzic

### Our Cities Have an API Problem. Startups Can Fix It.

Zach Caceres

### Research Twice, Build Once: How to Know Your Users as You Grow

Ryan Glasgow

### Grow or Die: A Framework for Turning Your Company Around Fast

Michael Mignano

### What Synthetic Embryos Can and Can’t Do, Now and in the Future

Magda Zernicka-Goetz and Nicole Neuman

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Bio & Science

### The Two Things We’ll Need for the Next AlphaFold

Daphne Koller and Nicole Neuman

### A Guide to Decentralized Biotech

Jocelynn Pearl

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Infrastructure

### What Is Negative Engineering?

Jeremiah Lowin

### How to Use Massive AI Models (Like GPT-3) in Your Startup

Elliot Turner

### PlanetScale CEO on Cloud-Prem and Climbing the Engineering Ladder

Sam Lambert and Derrick Harris

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* * *

Crypto & Web3

### What the Merge Means for Ethereum

Danny Ryan and Jeff Benson

### Info Diet: a16z Crypto’s Elena Burger

Elena Burger

### 7 Essential Ingredients of a Metaverse

Liz Harkavy, Eddy Lazzarin, and Arianna Simpson

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Data

### Data50: The World’s Top 50 Data Startups

Jennifer Li, Sarah Wang, and Jamie Sullivan

### Why SQL Needs Software Libraries

George Fraser and Derrick Harris

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* * *

Innovation & Creativity

### The Future of Search Is Boutique

Sari Azout

### AlphaFold, GPT-3 and How to Augment Intelligence with AI (Pt. 2)

Niko Grupen

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Leadership & Management

### How to Make Talent Scouts Work for You

Tyler Cowen and Daniel Gross

### Cloud Wars & Company Wars: Play Nice, But Win

Michael Dell, Marc Andreessen, Martin Casado, and Sonal Chokshi

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* * *

Sales & Go to Market

### Sales Enablement: The Underrated Cog of Enterprise Commercial Engines

Vassilis Tziokas

### Product-Market Sales Fit (What Comes First?)

Jyoti Bansal, Peter Levine, Satish Talluri, and Sonal Chokshi

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Marketplaces

### The Marketplace 100: 2022

Olivia Moore and Brandon Barros

### Hopper CEO on Super-App Ambitions and Becoming an Everything Startup

Frederic Lalonde and Theresa Fisher

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* * *

Social

### How Recommendation Algorithms Actually Work

Thomas Dimson

### The Future of Kidtech: A Web Browser for the Under-10 Set

Keith Schacht

### Unbundling Digital Identity Unlocks New Ways to Play and Build

Jon Radoff

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